THC-O versus THCP

The cannabis world is growing and expanding daily, especially considering the discoveries of new cannabinoids. If you’re part of the wellness community, you must have heard new names such as THC-O and THCP. Want to know more about these cannabinoids and the difference between them? Then this article will answer all of your questions.

What is THC-O?

THC-O is also known as THC acetate ester. The name indicates that THC has been molecularly changed by using acetic anhydride and sulfuric acid to produce THCO. THC-O is a synthetic version of delta-9 that does not occur naturally in cannabis. It is frequently chemically produced in the laboratory from delta-9 or 8. When the chemical is metabolized, THC-O and THC produce the same observable metabolite THC-COOH. THC-O is a prodrug that won’t fully work until the body breaks it down completely.

Because of the way its molecules are assembled, THC-O works well. The THC-O form has an acetate molecule, whereas the delta-9 variant does not. Understanding that THC-O can only be created in a lab is vital.

What is THCP?

THCP, short for 9-Tetrahydrocannabiphorol, is the most potent phytocannabinoid found in cannabis. It was discovered in 2019 by Italian researchers during the UNIHEMP project by accident.THCP is a naturally occurring cannabinoid that is found in specific cannabis cultivars.

The sole difference between THC and THCP is the addition of two carbons to the tail. Despite the tiny chemical difference, THCP is way more potent than THC. Scientists are particularly interested in THCP since it is thought to have 30 times the binding potential of THC. As a result, THCP has the potential to be ten times as potent as THC.

Delta 9 THC-P was found to bind to the endocannabinoid receptor cb1 roughly 33 times stronger than Delta 9 THC. Empirical evidence suggests that THCP is substantially more potent than THC, but only in particular ways. In most cases, THCP was diluted to less than 20% of the mixture. Most users perceive it as being stronger than D9 THC at this diluted level, with the most noteworthy difference being the claimed duration. Many users experience the effects for 12-24 hours, which is far longer than THC.

The difference between THC-O and THCP

Both THC-O and THCP come from the same family called “Tetrahydrocannabinols.’ But even though they’re from the same family, they have many differences.

The first thing to mention is that THC-O is synthetic, meaning the cannabis plant family did not naturally produce it. It was created in the lab, while THCP is a phytocannabinoid, meaning it’s naturally occurring. However, synthetic cannabinoids and phytocannabinoids both act on the endogenous cannabinoid system in the human body.

When comparing the strength and potency of these two, The efficacy of THCP is greater than that of THC-O. THCP is approximately ten times stronger than THC-O. But THC-O itself is more potent than regular THC by two-three times.

One more difference, unlike THCP, THC-O at high dosages can reportedly produce hallucinogenic and psychedelic effects, such as distorted vision and heightened emotional state. The reason why this happens is still unknown.

These two are different based on the time it takes for them to start working. THC-O takes a significantly longer time for the effects to kick in. THC-O must be appropriately digested before we may feel its effects. This is because THC-O is a prodrug to THC.

These two have in common that none are suitable for someone new to the cannabis world and hasn’t tried other types of cannabinoids first. The combined effects of these intoxicating cannabinoids may be pretty intense and overpowering when consumed simultaneously. Anxiety, and panic attacks, are a few of the possible side effects.

THC-O and THCP both have comparable effects. They may relieve tension and create soothing effects in lesser dosages. They may also help with pain, inflammation, and sleep issues. Higher dosages may worsen anxiety and stress.


Discovery of THC-O and THCP

The discovery of these two cannabinoids is quite different, and there is a significant time gap between them. There are claims that the US Army Chemical Corps conducted a series of dubious, top-secret medical studies on THC-O during the Edgewood Arsenal Experiments, which took place from 1949 to 1975.

As for the discovery of THCP, it was quite a recent event. It was first mentioned in a study published in late 2019 by Italian researchers working on a UNIHEMP project. The researchers employed cutting-edge technologies such as mass spectrometry and liquid chromatography to examine the plant parts closely. They also found CBDP, a kind of CBD.

Are THC-O and THCP both legal?

Just like with many other cannabinoids, the legality of these two is a debatable subject. Although the Controlled Substances Act (CSA) does not expressly prohibit these cannabinoids, they are considered THC analogs having chemical structures close to delta-9, potentially placing them under the Federal Analogue Act (FAA) by default. The FAA classifies all chemicals as either schedule I or schedules II restricted substances.

But on the other hand, they can be considered legal under the Farm Bill 2018 as long as they are derived from a hemp plant and don’t contain more than 0.3% THC by dry weight.

As you can see, legality is still quite a grey area for most cannabis products.

The Wrap

THCP and THCO are both forms of THC, although they do not have the same meaning. The most potent cannabinoid is THCP, while THCO is a highly useful version of THC. The molecular structure THCP has a seven-carbon chain tail. THCO entails adding acetate to the molecular structure of THC, which can be done with practically any cannabinoid, including THCP. Despite many inflated statements about how potent these two compounds are, there is no denying that they are more powerful than THC.

THC-O versus THCP is quite a debatable topic. It all comes down to personal preferences and the thing you’re looking for. After reading this article, it should be easier to choose which one is more suitable. You can find both at The Hemp Doctor in our newest and the most innovative Kayo Line, so if you’re planning to try any of the two, this is the right place to start.


As for the discovery of THCP, it was quite a recent event. It was first mentioned in a study published in late 2019 by Italian researchers working on a UNIHEMP project.
How Strong is THCP

THCP is a relatively new discovery in the wellness world, and people have many questions about it – primarily related to its strength. Researchers have found that THCP could potentially be 33 times more potent than THC, which has caused a stir in the cannabis community. This article will unravel all there is to know about this new addition to the cannabis family, if it’s safe and worth trying and how strong it is.

What is THCP?

THCP is short for Tetrahydrocannabiphorol, a naturally occurring phytocannabinoid in cannabis. It’s an analog of THC, accidentally discovered in 2019 by Italian researchers while working on a UNIHEMP research project. They published the report in late 2019.

The main distinction between THCP and THC is that THCP has two more carbons in its chemical structure. Although the structural difference isn’t huge, the researchers are especially interested in THCP since it potentially has 33 times the binding affinity of THC.

Although first discovered in a specific marijuana strain, THCP may also be produced in a laboratory by chemically modifying CBD derived from legal hemp plants. Most people who have taken THCP believe it is 5 to 10 times stronger than THC. However, the exact strength of THCP is still being contested because all of our evidence comes from single research.

How strong is THCP?

How strong THCP is is amongst the most frequently asked questions about THCP. Increased interest and the main selling point of THCP are due to its high potency resulting from the unique way THCP binds to cannabinoid receptors.

THCP is expected to be more potent than THC. To be more exact, the THCP bound to both receptors robustly,

How long does THCP take to kick in?

THCP products, like any other cannabinoid, come in various forms. And the period required to observe the results varies depending on the product. Edibles take longer than other products, but their effects last the longest. Edibles take around an hour to start working, and results will continue to increase for the next hour. These effects are most substantial for around 2 hours before gradually fading. The entire process lasts 4 to 6 hours.

THCP, in vape form, acts faster – within roughly 15 minutes. A peak experience is obtained after one hour and begins to fade after around two hours.

THCP Dosage

Since we still need more information about THCP, there is no clear-cut answer to this question. But knowing that it is more potent than THC, you should take a lower dose, start small and observe its effects until you increase the intake.

The adequate dose of THCP might range between 1 and 4mg. Consumers should begin with a 0.3mg dosage and work their way up. It’s easy to take too much THCP and get unwanted side effects, so it’s best to start with tiny dosages.


What are the effects of THCP?

The Italian team discovered physiological effects when researching the impact of THCP on human cannabinoid receptors, including pain relief, temperature reduction in the rectum, and hypomobility.

THCP  has roughly the same effects as THC but with more strength. The researchers that discovered THCP in 2019 said that “the finding of a powerful THC-like phytocannabinoid may shed light on various pharmacological effects not simply attributable to [delta 9 THC]” in marijuana.

Of course, making medical claims before having more thorough research on this compound is impossible, but many users have reported various effects.

Is THCP legal?

Although THCP isn’t listed under the prohibited substance list, its legality is still quite a grey area.

However, Hemp and all its compounds and derivatives with less than 0.3% THC have been legalized under Farm Bill 2008. A federal appeals court affirmed in May 2022 that delta 8 THC is a legitimate hemp product—a finding that appears to be relevant to other hemp-derived goods. Keep in mind that specific states can have their own rules regarding their legality.

Will THCP make you fail the drug test?

Because THCP has not been adequately investigated, it is uncertain if it will cause you to fail a drug test. However, there is no reason to suppose that THCP does not produce regular THC breakdown products in the human body that routine drug tests would detect. Since we don’t have a specific answer for now no, it is best to stay away from THCP for the time being if you have to get a drug test done shortly.

The wrap

The realm of THCP is still in its early stages. With so much interest in the alternative cannabinoid field, it’s challenging to envision THCP not being more readily available as the industry matures.  From what we know now, THCP has the highest potency than any other cannabinoid on today’s market, but knowing exact numbers and comparisons calls for more research and studies.

A comprehensive study on THCP is still required to understand its effects on consumers better. However, a great variety of cannabinoids, such as delta 8 THC, delta 9 THC, THC-O, and HHC, are readily available for consumers wanting to indulge in the newest and the most innovative cannabis products. If you’re going to experiment with new hemp-derived cannabinoids, start with a low dose. Also, make sure to get the product from a reputable brand whose products have been through third-party lab testing. One such brand is The Hemp Doctor. We offer various cannabinoid products for consumers of every taste that undergo rigorous testing and advanced production and manufacturing steps using only top-quality ingredients.


The Italian team discovered physiological effects when researching the impact of THCP on human cannabinoid receptors, including pain relief, temperature reduction in the rectum, and hypomobility.

Step 1: Organic Farming

Learn more About The Hemp Doctor's
100% Organic Process

Our Process

THC Delta-8 Hemp
Derived Cartridge

These 1ml premium THC delta 8 vape cartridges are derived from US grown hemp and are federally legal.

$27.50 - $45.00

Shop Products

Delta-8 THC Edible

Medibles, now available in 5 delicious flavors. Blue Razz (Blue Raspberry), Watermelon, Pineapple, Cherry, and Green Apple.


Shop Products

All Natural Goodness

The Hemp Doctor Hemp Oil / Made in USA Shop Products

What Our Clients Say.


"This shop has a vast knowledge of what they are selling and how to use it properly. [...] The Hemp Doctor is there to honestly help you. I am very Thankful they opened their doors!"
- Diane